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tagD [2019-08-12 09:08:52]
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tagD [2019-08-12 09:08:52]

glycerol-3-phosphate cytidylyltransferase
locus
BSU_35740
pI
5.67
mw
15.13 kDa
protein length
129 aa Sequence Blast
gene length
390 bp Sequence Blast
function
biosynthesis of teichoic acid
product
glycerol-3-phosphate cytidylyltransferase
essential
yes
ec
2.7.7.39
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    3,680,581 3,680,970

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol (according to Swiss-Prot)

    • Protein family

  • cytidylyltransferase family (with [protein|CF9633F769263C6D16EE778F6BD2ECF1995F512A|IspD] and [protein|B25AE6979AF12628780C4489FFED966C6B31968A|YfnH], according to UniProt)

    • Structure

  • [PDB|1N1D] (complex with CDP-glycerol) [Pubmed|10508782], [PDB|1COZ]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]-[gene|88028A5F3520CB6DAB014412974EB59CC5D226DD|tagE]-[gene|E730E41546298960A4B907FCB7F36C495AA9602B|tagF]-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7581998], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: repression, [Pubmed|9457886], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]
  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR]: activation, [Pubmed|12950927], in [regulon|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR regulon]

    • regulation

  • repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]
    • view in new tab

    References

    Reviews

  • 24024634

    • Original publications

  • 9683503,9457886,11673441,10508782,2507871,12950927,7581998,20525796,22383849